Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells
Identifieur interne : 002611 ( Main/Exploration ); précédent : 002610; suivant : 002612Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells
Auteurs : Alain R. M. Townsend [Royaume-Uni] ; Patricia M. Taylor [Royaume-Uni] ; Andrew L. Mellor [Royaume-Uni] ; Brigitte A. Askonas [Royaume-Uni]Source :
- Immunogenetics [ 0093-7711 ] ; 1983-03-01.
English descriptors
- Teeft :
- Askonas, Clone, Cosmid, Cytotoxic, Cytotoxic clones, Cytotoxic response, Donor mice, Expression products, Fluorescent cells, Functional properties, Gene, Gene products, Gene region, Growth factors, Indirect immunofluorescence, Influenza, Influenza virus, Influenza virus strains, Intranasal infection, Locus products, Medical research, Microtiter plates, Mill hill, Moloney leukemia virus, Monoclonal antibodies, Mutant, Mutant target cells, Mutant targets, National institute, Open symbols, Other clones, Polyclonal populations, Protein domains, Responder, Responder cells, Restriction element, Results show, Single genes, Spleen, Spleen cells, Stimulator, Stimulator cells, Surface phenotype, Syngeneic, Syngeneic spleen cells, Target cells, Townsend, Uninfected, Uninfected targets, Unpublished data, Viral components, Virus specificity.
Abstract
Abstract: A series of 16 H-2b-restricted, A influenza virus-specific cytotoxic T-cell clones are described and characterized. One is Kb restricted, the others Db restricted. The factors governing Kb or Db restriction patterns seen in the mixed populations from which clones are derived are investigated. The Kb-restricted clone does not recognize Kb mutant bm1 and influenza and all 15 Db-restricted clones do not recognize Db mutant bm14 and A influenza virus; these results are discussed in the light of findings in a variety of other viral systems. Representative Kb- and Db-restricted clones were used to assess the functional properties of cloned cosmids containing either Kb or Db genes expressed in transformed L-cells (κ haplotype). The expression products of both cosmids functioned efficiently as mutually exclusive restriction elements for A influenza virus recognition.
Url:
DOI: 10.1007/BF00364412
Affiliations:
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Le document en format XML
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Askonas</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Medical Research, NW7 1AA, Mill Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunogenetics</title><title level="j" type="abbrev">Immunogenetics</title><idno type="ISSN">0093-7711</idno><idno type="eISSN">1432-1211</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1983-03-01">1983-03-01</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="283">283</biblScope><biblScope unit="page" to="294">294</biblScope></imprint><idno type="ISSN">0093-7711</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0093-7711</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Askonas</term><term>Clone</term><term>Cosmid</term><term>Cytotoxic</term><term>Cytotoxic clones</term><term>Cytotoxic response</term><term>Donor mice</term><term>Expression products</term><term>Fluorescent cells</term><term>Functional properties</term><term>Gene</term><term>Gene products</term><term>Gene region</term><term>Growth factors</term><term>Indirect immunofluorescence</term><term>Influenza</term><term>Influenza virus</term><term>Influenza virus strains</term><term>Intranasal infection</term><term>Locus products</term><term>Medical research</term><term>Microtiter plates</term><term>Mill hill</term><term>Moloney leukemia virus</term><term>Monoclonal antibodies</term><term>Mutant</term><term>Mutant target cells</term><term>Mutant targets</term><term>National institute</term><term>Open symbols</term><term>Other clones</term><term>Polyclonal populations</term><term>Protein domains</term><term>Responder</term><term>Responder cells</term><term>Restriction element</term><term>Results show</term><term>Single genes</term><term>Spleen</term><term>Spleen cells</term><term>Stimulator</term><term>Stimulator cells</term><term>Surface phenotype</term><term>Syngeneic</term><term>Syngeneic spleen cells</term><term>Target cells</term><term>Townsend</term><term>Uninfected</term><term>Uninfected targets</term><term>Unpublished data</term><term>Viral components</term><term>Virus specificity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A series of 16 H-2b-restricted, A influenza virus-specific cytotoxic T-cell clones are described and characterized. One is Kb restricted, the others Db restricted. The factors governing Kb or Db restriction patterns seen in the mixed populations from which clones are derived are investigated. The Kb-restricted clone does not recognize Kb mutant bm1 and influenza and all 15 Db-restricted clones do not recognize Db mutant bm14 and A influenza virus; these results are discussed in the light of findings in a variety of other viral systems. Representative Kb- and Db-restricted clones were used to assess the functional properties of cloned cosmids containing either Kb or Db genes expressed in transformed L-cells (κ haplotype). The expression products of both cosmids functioned efficiently as mutually exclusive restriction elements for A influenza virus recognition.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Townsend, Alain R M" sort="Townsend, Alain R M" uniqKey="Townsend A" first="Alain R. M." last="Townsend">Alain R. M. Townsend</name></region><name sortKey="Askonas, Brigitte A" sort="Askonas, Brigitte A" uniqKey="Askonas B" first="Brigitte A." last="Askonas">Brigitte A. Askonas</name><name sortKey="Mellor, Andrew L" sort="Mellor, Andrew L" uniqKey="Mellor A" first="Andrew L." last="Mellor">Andrew L. Mellor</name><name sortKey="Taylor, Patricia M" sort="Taylor, Patricia M" uniqKey="Taylor P" first="Patricia M." last="Taylor">Patricia M. 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